Research to advance disease therapies, understand cosmic rays among cargo headed to space station

NASA Astronaut Jack Fischer works within the Japanese Experiment Module on CASIS PCG 6. CASIS PCG 7 will utilize the orbiting laboratory’s microgravity environment to grow larger versions of Leucine-rich repeat kinase 2 (LRRK2), implicated in Parkinson’s disease. Credit: NASA

The SpaceX Dragon cargo spacecraft is targeted for launch August 14 from Kennedy Space Center for its twelfth commercial resupply (CRS-12) mission to the International Space Station.

The flight will deliver investigations and instruments that study cosmic rays, protein crystal growth, stem cell-mediated recellularization and a nanosateliite technology demonstration. The vehicle will also deliver crew supplies and equipment to crew members living aboard the station.

Here are some highlights of research that will be delivered:

Investigation studies cosmic rays

Cosmic rays reach Earth from far outside the solar system with energies well beyond what man-made accelerators can achieve. The Cosmic Ray Energetics and Mass (CREAM) instrument, attached to the Japanese Experiment Module Exposed Facility, measures the charges of cosmic rays ranging from hydrogen to iron nuclei. The data collected from the CREAM instrument will be used to address fundamental science questions such as:

  • Do supernovae supply the bulk of cosmic rays?
  • What is the history of cosmic rays in the galaxy?
  • Can the energy spectra of result from a single mechanism?

Tested in several long duration balloon flights, the CREAM instrument holds the longest known exposure record for a single balloon-borne experiment at approximately 160 days of exposure. CREAM’s three-year mission will help the scientific community build a stronger understanding of the fundamental structure of the universe.

Human lung scaffold pieces can be made for use as a scaffold to support growth of bioengineered lung for research studies like Lung Tissue. The cells are grown in a specialized framework that supplies them with critical growth factors so that scientists can observe how gravity affects growth and specialization as cells become new lung tissue. Credit: Joan Nichols, UTMB

Microgravity-grown protein crystals aid in understanding of Parkinson’s disease

The microgravity environment of the allows protein crystals to grow larger and in more perfect shapes than earth-grown crystals, allowing them to be better analyzed on Earth. Developed by the Michael J. Fox Foundation, Anatrace and Com-Pac International, the Crystallization of Leucine-rich repeat kinase 2 (LRRK2) under Microgravity Conditions (CASIS PCG 7) investigation will use the orbiting laboratory’s microgravity environment to grow larger versions of this important protein, implicated in Parkinson’s disease.

Defining the exact shape and morphology of LRRK2 would help scientists to better understand the pathology of Parkinson’s and aid in the development of therapies against this target.

Existing CREAM hardware used for balloon flights. The origins of cosmic rays and the mechanisms that accelerate them to high speeds are among the oldest questions in modern astrophysics. Results from CREAM bring the science community closer to answering those questions, and build a stronger understanding of the fundamental structure of the universe. Credit: NASA

Telescope-hosting nanosatellite tests new concept

The Kestrel Eye (NanoRacks-KE IIM) investigation is a microsatellite carrying an optical imaging system payload. This investigation validates the concept of using microsatellites in low-Earth orbit to support critical operations, such as providing lower-cost Earth imagery in time-sensitive situations such as tracking severe weather and detecting natural disasters.

Sponsored by the space station U.S. National Laboratory, the overall mission goal for the investigation is to demonstrate that small satellites are viable platforms for providing critical path support to operations and hosting advanced payloads.

Growth of lung tissue in space could provide information about disease pathology

The Effect of Microgravity on Stem Cell Mediated Recellularization (Lung Tissue) uses the of space to test strategies for growing new . Using bioengineering techniques, the Lung Tissue investigation cultures different types of cells in controlled conditions aboard the space station. The cells are grown in a specialized framework that supplies them with critical growth factors so that scientists can observe how gravity affects growth and specialization as cells become new lung tissue.

Tissue mimic models such as this also have the potential to be used for assessing drug or chemical toxicity by biotechnology and pharmaceutical companies and could allow for rapid testing of new chemicals and compounds, considerably lowering the overall costs for research and development of new drugs. The ultimate goal of this investigation is to produce bioengineered human lung tissue that can be used as a predictive model of human responses allowing for the study of lung development, lung physiology or disease pathology.

These investigations and others launching aboard CRS-12 will join many other investigations currently happening aboard the station. Follow for more information about the science happening on station.

Leave a Comment